Research on taurine in anti-tumor immunity and improving cancer treatment efficacy

Tumor cells compete with CD8+T cells for taurine by expressing the taurine transporter SLC6A6, which induces T cell death and exhaustion, leading to tumor immune escape and promoting tumor progression and recurrence. Supplementing taurine can reactivate exhausted CD8+T cells and improve cancer treatment efficacy.

《Cancer SLC6A6-mediated taurine uptake transactivates immune checkpoint genes and induces exhaustion in CD8+T cells》

发表平台：《Cell》

发表时间：2024年 4月

关键结论：来自空军军医大学西京医院的研究团队发现了牛磺酸在抗肿瘤免疫领域的用途。癌症相关的牛磺酸消耗会诱导T细胞衰竭和促进免疫逃逸，因此补充牛磺酸则能让原本衰竭的CD8+T细胞“重振旗鼓”，从而提高癌症疗法疗效。